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Neuroprotective Effect of Sesamol in Glioma Induced in Rats

Rangarajan Narasimhan, Muthukumar Vaithiyanathan, Vanisree Janardanam

Abstract


Malignant gliomas are the most common type of brain tumor in adults. These tumors are highly invasive and despite multi-modality treatment the mean survival of patients is still less than 1 year. The present study was aimed to investigate the antioxidant potential of Sesamol in glioma induced rats. Experimentally glioma was induced in adult male Wistar rats (250–300 g) by intracerebral injection of C6 cells (4x104 cells /rat). The effect of oral administration of sesamol (20mg/kg B.wt) on AST, ALT, LDH, CK and oxidative stress biomarkers in the brain tissue of normal and experimental animals were analyzed. Glioma induced rats showed a significant increase in the activities of enzymes (AST, ALT, LDH, CK and GST) and TBARS. The levels of ascorbic acid, tocopherol, reduced glutathione and activities of superoxide dismutase, catalase, glutathione peroxidase and Na+-K+ ATPase were significantly decreased in the brain tissues. Treatment with sesamol restored the above mentioned changes in glioma induced rats. These preliminary findings suggest that sesamol exhibits neuroprotective effect against glioma induced changes in the rat brain.


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