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Treatment of Fulminant Hepatitis B with Oral Hepatitis B Vaccine

Alireza Ghaffari, Kamyar Ghabili, Mahtab Rezazadeh, Hamid Noshad


Fulminant hepatitis is a rare complication of hepatitis B virus infection. This condition has a high mortality rate and liver transplantation is often necessary to save life. The present report highlights the value of a short course of oral hepatitis B vaccine therapy in the treatment of a patient with fulminant hepatitis secondary to HBV infection. This information could be of value in the development of new therapeutic measures based on the immune tolerance mechanisms for this fatal condition. The use of oral vaccine therapy for treatment of fulminant hepatitis needs approval for use in appropriately-sized clinical trials.

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