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Comparison of Inflammatory Responses After Acute Moderate Aerobic Cycling in Healthy Young Active and Inactive Men

Ebrahim Akhtari-Shojaei, Afshar Jafari, Hossein Namdar, Adalat Farajov, Majid Khalili

Abstract


In view of available findings about exercise-induced inflammation, the present study was conducted to investigate the effect of acute moderate cycling on systemic inflammatory responses in healthy young active and inactive men. A quasi-experimental pre-post design was used to study 12 healthy young inactive men (aged 21.01 ± 1.1 years, body fat 16.7 ± 1.2% and VO2max 45.01 ± 5.83 ml/kg/min) and 12 young active men (aged 21.02 ± 1.2 years, body fat 12.04 ± 2.72% and VO2max 59.63 ± 2.15 ml/kg/min). One week after preliminary measurements, all subjects participated in an acute moderate cycling protocol (45 min with 50% VO2max). Blood samples were drawn before and immediately after the exercise. Complete blood cell counts, fasting blood sugar, serum interleukin-6 (IL-6), interleukin-10 (IL-10), C-reactive protein (CRP) and plasma stress hormones (cortisol and epinephrine) were determined. Data were analyzed by the independent samples t-test and Pearson's correlation test at ? < 0.05. Our results demonstrated that total and differential circulating leukocyte counts and serum IL-6, IL-10, and CRP concentrations, along with plasma epinephrine and cortisol levels, were increased immediately after the acute moderate cycling protocol in both active and inactive men (P < 0.01). Furthermore, the positive correlation between the post-exercise total leukocyte counts and serum IL-10 was significant (P = 0.011). However, the correlations between the exercise-induced reduction of fasting blood glucose and total leukocyte counts with serum CRP and IL-6 after exercise were not significant (P > 0.05). The small exercise-induced elevation of inflammatory marker concen-trations suggests that the intensity or duration of the acute moderate cycling episode may not have been sufficient to induce a substantial systemic inflammatory response in young active or inactive men. Therefore, it can be concluded that the moderate exercise appears to be safe from an immunological point of view in young active and inactive men, and moderate exercise cycling can be recommended for both groups.

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